Posted by SLS on July 17, 2006, at 9:56:39
In reply to Re: 1/2 an emsam patch - both types of mao inhibit » SLS, posted by Donna Louise on July 17, 2006, at 5:50:15
> > > I know that the 6mg patch is equivalent to 40mg dose of selegiline.
> >
> > Where can I find more information on this?
> >
> >
> > - Scott
>
> Scott, it is all in the whatchacallit that comes in the package with the drug. PI sheet? There is a graph too. I don't know where the idea that 6mg =40mg. According to this package info, transdermally you get about 3 1/2 times the amount you get orally. So, 6mg orally=20mg transdermally. 9mg=30 and 12mg=40. This is why I didn't get the most relief until 12 mg patch as it takes 40mg for me to get enough MAOI A deanimation.
I looked at the drug monograph PDF from BMS and on rxlist.com, and couldn't find anything that addressed my question. This issue is really bugging me. I am getting the impression that the 12mg/24hr patch is giving you a plasma level of selegiline that is quite a bit higher than that you would receive from taking a 40mg oral dose.You would think that you could find a bunch of stuff on Medline stating quite simply what the relative pharmacokinetics are between the two preparations, but you can't.
- Scott
poster:SLS
thread:666394
URL: http://www.dr-bob.org/babble/20060717/msgs/667722.html