Posted by hgi698 on June 21, 2006, at 20:28:21
In reply to Antipsychotic/SSRI Withdrawal Euphoria, posted by hgi698 on June 21, 2006, at 14:15:50
From what I have read the d1 receptor subtype is found in large numbers in the prefrontal cortex the area of the brain behind your forehead. I believe that activation of this subtype of receptor allievates apathy, poor attention and increases verbal fluency. The verbal fluency is important because it explains why some people always seem to say the right thing, while others have nothing interesting to say. The D2 receptors especially the ones located in the nucleus accumbens are associated with feelings of pleasure. Stimulation of these receptors decreases anhedonia and increases locomotor activity. Locomotor activity is basically how fast you talk. Depressed people have psychomotor retardation and talk very slow. While manic people talk too fast. So for me increasing dopamine is good but it leads to down regulation of the receptor and a loss of good effect. That's why i was wondering if the antipsychotic could upregulated those receptors. Of course it seems like the risks could be fairly substantial. I wonder though if it is possible that those receptors would upregulated semi-permanently. Obviously you wouldn't want psychoses or tardive dyskinseas. There was an article i read referring to antidepressant effects of antipsychotic withdrawal. I can't find it though. Maybe the receptors would downregulate again after time, i don't know. If anybody is has any binding affinities for typical antipsychotics or other knowledge on this subject, it would be appreciated.
poster:hgi698
thread:659752
URL: http://www.dr-bob.org/babble/20060617/msgs/659916.html