Posted by willyee on May 18, 2006, at 22:42:40
I see a question asked about maoi use,its start,etc.I posted this once,maybe twice,i dont believe its no longer on the net,so ill post it again,its a small snip from a very large article,the snip is the only relavent part.But here is how the birth of parnate came about.
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"Alfred Burger was born in Vienna, Austria on September 6, 1905 and received his Ph.D. degree from the Universität Wien in 1928. The following year he joined the Drug Addiction Laboratory at the University of Virginia, where he synthesized the morphine molecule in an attempt to find the analgesic pharmacophore. In 1938 he joined the university’s chemistry faculty, where he served as Professor of Chemistry and Department Chairman. Largely because of his efforts the department became the major training ground for medicinal chemists, and he is regarded as a major driving force in establishing medicinal chemistry as an independent science in the United States.
Burger’s research specialty was analgesics, antidepressants, and chemotherapeutic agents. One of the few academicians to have a drug designed and synthesized in his laboratory and brought to market (Parnate, a monoamine oxidase [MAO] inhibitor), he was the recipient of numerous awards and lectured throughout the world during his long and distinguished career. He founded the Journal of Medicinal Chemistry (in 1958 and was its editor until 1971) and Medicinal Chemistry Research (in 1991 and was its editor for the first year before becoming editor emeritus). In 1978 GlaxoSmithKline established the biennial American Chemical Society Alfred Burger Award in Medicinal Chemistry “to recognize outstanding contributions to research in medicinal chemistry.”
Despite his battle with Parkinson’s disease, Burger made his last public appearance at a meeting of medicinal chemists when he delivered the opening remarks (reprinted in the reference set under review here) at the ACS 26th Medicinal Chemistry Symposium, chaired by Donald J. Abraham and held at Virginia Commonwealth University in Richmond on June 14, 1998. In 1998 VCU established the Alfred Burger Professorship in Medicinal Chemistry. In addition to his scholarly works Burger wrote popular books such as his last published work, written at age 90, Understanding Medications: What the Label Doesn’t Tell You (For a review see (Kauffman, L. M.; Kauffman, G. B. Am. Sci. 1996, 84, 409). He died on December 30, 2000 at the age of 95."
poster:willyee
thread:645751
URL: http://www.dr-bob.org/babble/20060515/msgs/645751.html