Posted by djmmm on March 6, 2006, at 9:53:46
In reply to Re: anti-oxidants for (possible) TD prevention » med_empowered, posted by ed_uk on March 5, 2006, at 14:15:33
> Hi Meddie
>
> I think I've heard of lecithin being used too.
>
> Eda good powerful antioxidant, like vit. E, or perhaps a potent brain specific antioxidant like melatonin would help. I think most research supports Vitamin E... there has been some success with manganese, and as I stated earlier, melatonin.
Vitamin E:
Elkashef AM, Wyatt RJ. Tardive dyskinesia: possible involvement of free radicals and treatment with vitamin E. Schizophr Bull. 1999;25:731–740.
Adler LA, Edson R, Lavori P, et al. Long-term treatment effects of vitamin E for tardive dyskinesia. Biol Psychiatry. 1998;43:868–872.
Lohr JB, Lavori P. Whither vitamin E and tardive dyskinesia? Biol Psychiatry. 1998;43:861–862.
Also there has been some research on :BCAAs (Branch chain amino acids:
Richardson MA, Bevans ML, Weber JB, et al. Branched chain amino acids decrease tardive dyskinesia symptoms. Psychopharmacology (Berl). 1999;143:358–364.
Richardson MA, Small AM, Read LL, et al. Branched chain amino acid treatment of tardive dyskinesia in children and adolescents. J Clin Psychiatry. 2004;65:92-96.
Richardson MA, Bevans ML, Read LL, et al. Efficacy of the branched-chain amino acids in the treatment of tardive dyskinesia in men. Am J Psychiatry. 2003;160:1117-24.
DMAE:Casey DE, Denney D. Dimethylaminoethanol in tardive dyskinesia [letter]. N Engl J Med. 1974;291:797.
Re' O. 2-Dimethylaminoethanol (deanol): a brief review of its clinical efficacy and postulated mechanism of action. Curr Ther Res Clin Exp. 1974;16:1238–1242.
Alphs L, Davis JM. Noncatecholaminergic treatments of tardive dyskinesia. J Clin Psychopharmacol. 1982;2:380–385.
Melatonin:Shamir E, Barak Y, Shalman I, et al. Melatonin treatment for tardive dyskinesia: a double-blind, placebo-controlled, crossover study. Arch Gen Psychiatry. 2001;58:1049–1052.
Nelson LA, McGuire JM, Hausafus SN. Melatonin for the treatment of tardive dyskinesia. Ann Pharmacother. 2002;37:1128-31.
Niacin:Kunin RA. Manganese and niacin in the treatment of drug-induced tardive dyskinesias. J Orthomol Psychiatry 5:4-27, 1976. In: Werbach MR. Nutritional Influences on Illness [book on CD-ROM]. 2nd ed. Tarzana, CA. 1996.
Vitamin B6:Lerner V, Miodownik C, Kaptsan A, et al. Vitamin B6 in the treatment of tardive dyskinesia: a double-blind, placebo-controlled, crossover study. Am J Psychiatry. 2001;158:1511–1514.
poster:djmmm
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