Posted by yxibow on February 18, 2006, at 16:35:03
In reply to Re: Barbiturates » yxibow, posted by ed_uk on February 18, 2006, at 12:27:51
> Hi Yxi
>
> >the one thing and I've mentioned this before, that they leave out of the report about atypicals vs old line drugs is the gobs of Cogentin that one has to take because they would be climbing the walls with akathisia
>
> Akathisia doesn't necessarily occur if the dose is appropriate. Akathisia tends to occur when an excessively high proportion of D2 receptors are blocked by an inappropriately high dose.An ED of Haldol can exceed the threshold of akathisia easily.
>
> I once took prochlorperazine (Compazine, Stemetil) and suffered no akathisia......the dose was low. I got bad akathisia with chlorpromazine (Thorazine, Largactil) at a high dose, but none whatsoever at a low dose.Its the other things that worry me about that study too... we don't know, its true, but there was a giant study on your side of the pond in the BJP which estimated the emergence of TD with Zyprexa to be around 1/2% per year, and one can extrapolate that Seroquel is quite even smaller. That's the quality of life also that I'm referring to. With thousands of patient hours we have known high numbers of TD emergence with old line, especially the oldest. Also, Geodon isn't the only one with a QTc interval issue, Mellaril has a worse issue with QTc elongation.
Cheers
Jay
poster:yxibow
thread:609056
URL: http://www.dr-bob.org/babble/20060212/msgs/610940.html