Posted by rod on October 18, 2005, at 17:53:22
In reply to Re: Smoking - Core Symptoms Depression - Selegilin » rod, posted by Declan on October 18, 2005, at 16:40:05
> You were saying that with sublingual admin there were't any sleep problems or amphetamine metabolites.
> IYou mean because less deprenyl/selegeline is taken?
Hi Declan,Its not because the dosage is smaller, its just because it bypasses first pass metabolism in the liver.
Either 1,25 mg Xilopar or 10mg regular Selegiline (swallowed) results in the same plasma level of Selegiline. You are just bypassing the liver and therefore vitually no selegiline gets transformed into amphetamine metabolites. If you take Xilopar "nothing gets wasted" (well depending on your view. some might like the amphetamine stuff). Only 1/8 of the 10mg oral selegiline will reach your bloodtream, if swallowed, regulary.And actually its not called "sublingual". Oficially it called a "Lyo-tablet" (Lyo (Greek) meaning loose or free). If you put it on your tounge, it melts within a few seconds. The prescription info doesnt tell more on how to take it, other than you should not eat anything for 5 minutes afterwards.
I always try to dispense it on the oral mucosa and wait a minute before I swallow it. But I dont see any difference to a sublingual tab.. (note the I :) )And I am really not sure (I simply dont know) if you can absorb a regular selegiline tab (chip of a tab) under your tounge. I can imagine there might be some "helper substances" necessay or it has to dissolve really "fine" (like Xilopar)
hope I could clarify any obscurities :)
sleep well, world :)
bye
Roland
poster:rod
thread:566787
URL: http://www.dr-bob.org/babble/20051017/msgs/568619.html