Posted by 4wd on October 16, 2005, at 15:43:06
In reply to Re: nardil-more NE and DE at higher doses » 4wd, posted by SLS on October 13, 2005, at 12:02:08
> > If Nardil is sedating why does it cause insomnia?
>
> Hi Marsha.
>
> Have you ever felt really tired, fatigued, and subdued without being sleepy?About 80 percent of the time. :-)
(except of course when I'm buzzing with freaky nervous fear).
Have you ever been sleepy and still not able to fall asleep? Nardil seems to possess both stimulant and sedative properties. I don't want guess at the mechanisms behind each of these. It is tempting to want to always explain things by looking only at the "levels" of the three main monoamine neurotransmitters (NE, DA, 5-HT). It is quite possible that the insomnia is not caused by MAO inhibition, but rather by some other unrelated pharmacological property. Alternatively, MAO inhibition might be responsible for divergent activities in different brain circuits that are normally kept in balance by feedback mechanisms between the two that can no longer be maintained because of the indescriminant increase in neurotransmitter levels.That makes sense. It will be nice someday when we have ad that will increase neurotransmitter levels individually and allow us to titrate each one indivually. I.e. I need 55% SE reuptake inhibition, 18% NE reuptake inhibition and 27% DE reuptake inhibition. Better yet, lets go for the individual receptors.
I guess first we need a bit more of a clue what each receptor does.
Marsha
> Parnate is a different beast in that it can cause profound sleepiness during the middle of the day and insomnia at night. Some of this might be due to the amphetamine-like effects of the drug and its metabolites.
>
>
> - Scott
poster:4wd
thread:565365
URL: http://www.dr-bob.org/babble/20051010/msgs/567721.html