Posted by Declan on August 19, 2005, at 18:49:46
In reply to Re: citrus and Adderall - please explain, posted by crazychickuk on August 19, 2005, at 18:22:17
Flavanoids in the grapefruit inhibiting liver enzymes??
This is a quote about grapefruit. (I dunno if it is at *all* relevant to Adderal).
'The major interaction seems to be in the gut wall with enzymes belonging to various cytochrome P-450 subfamilies. It also appears to inhibit renal 11-beta-hydoxysteroid dehydrogenase in humans and could therefore potentiate side effcts from licorice. Although the flavanoids naringen and naringenin were first implicated, they are probably not the only active components. In fact the furanocoumarin bergamottan and related compounds appear to be largely responsible for this activity. This ability of plant furanocoumarins to inhibit drug metabolising enzymes was first noted by Korean researchers in 1983. This phenomenon raises the question of how other plants and their phytochemicals may influence the bioavailability of both drugs and herbal constitiuents.'
(So much for the food/drug dichotomy).
But there is a thing about the metabolism of amphetamine being ph dependant too. Alkalysing your urine will retard excretion and acidifying it will increase it.
Declan
poster:Declan
thread:543962
URL: http://www.dr-bob.org/babble/20050816/msgs/543990.html