Posted by MoparFan91 on August 11, 2005, at 19:12:33
I was in a bind with bad depression for a couple weeks or so. When things got real rough, I took 1/2 of a 5mg tablet of Abilify that I had leftover from previous trial. It got me out of the depression over night, and I managed to go back to work later that the morning. My doctor now officially has me on it at 2.5mg/day, and it seems to be clearing my mind somewhat, giving me some motivation, and helping a bit with depression.
On my previous trial of Abilify, I took 10mg a day. But. that was too much, and I had a bit of akathisia, insomnia, brain dead, overheating, and some other side effects. With 2.5mg, I don't seem to have those as far as I can tell?
Anyone have experience with taking only 2.5mg of Abilify a day?
I've noticed that many have problems with it, but they are on much higher doses like 10-20mg/day. I wonder if lower doses would work better in those cases.
Another question: I read that some atypical neuroleptics at very low doses preferentially antagonize presynaptic dopamine receptors. This indirectly increases dopamine release. Does Abilify at low doses do this as well?
Abilify also has a dopamine partial agonist built in too when dopamine levels get too low (hence DSS, or dopamine system stabilizer). Additionally it agonizes the 5-ht1a receptor. Does that mean it a serotonin agonist as well? If so, is that part of it's antidepressant effect?
and what mechanism of Abilify made it helped my depression so quick?
poster:MoparFan91
thread:540416
URL: http://www.dr-bob.org/babble/20050811/msgs/540416.html