Posted by linkadge on July 23, 2005, at 17:49:55
In reply to Re: Remeron for OCD » linkadge, posted by ed_uk on July 23, 2005, at 16:48:46
I was under the impression that neuroleptic augmentation of SSRI's was thought to work through d2 antagonism after case reports found that haldol showed clear augmentation of clomipramine in OCD.
The only reason I wonder about the 2a/c receptors is because that blocade of these receptors further increase dopamine output in the frontal cortex, which is generally hyperdopaminergic in OCD.
Surprisingly, there is sufficant evidence that the hallucinogen psilocybin 2a/c agonist posesses significant antiobsessive action.http://www.maps.org/research/psilo/azproto.html
5-ht2c agonism might be ralavant to sexual obsessions, since agonism of the 5-ht2c recpetor decrease dopamine in the NAA, and generally reduces sexual behavior.
http://www.szote.u-szeged.hu/psych/abir1.htmlChou-Green JM, Holscher TD, Dallman MF, Akana SF. Compulsive behavior in the 5-HT2C receptor knockout mouse. Physiol Behav 2003; 78: 641-649.
Does periactin have any effect on our OCD? It made me afraid of microwaves again.Linkadge
poster:linkadge
thread:532182
URL: http://www.dr-bob.org/babble/20050723/msgs/532285.html