Posted by willyee on May 29, 2005, at 16:52:50
In reply to Re: Parnate not so good for melancholy » SLS, posted by Maxime on May 29, 2005, at 16:42:45
> So if I added Trytophan, it might help? I know it's contraindicated but I wonder if it's one of those contraindications that you can ignore - LOL!
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> What would your suggestion be Scott?
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> Maxime
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> > It is my belief that Nardil is more serotonergic than Parnate. I believe this makes a significant difference in its psychotropic effects. Serotonergics seem to be better "mood-brighteners" than noradrenergics. Noradrenergics might convey more energy - as does Parnate - but without serotonin, there is a lack of "feeling good" about things. Nardil also affects GABA systems. However, I could only guess as to whether this contributes to its anti-melancholic profile. It might prevent hyperactivity in the subgenual cingulate.
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> > - Scott
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>Might why again i had such a response to parnate after stopping nardil without a washout.
I know its taboo but i am curious of the effect of taking both.All i know is if parnate responded like that everyday it would be THE med.Also to your other post,im limited to getting deep into pharmocology,but the way parnate leaves u feeling empty the next day as if its all gone and u have to start the build up all over again is annoying to say the least,and also makes it feel somewhat reversable where as nardil seemed to have a im here feeliing,for me however alone it just wasnt helping.
poster:willyee
thread:504827
URL: http://www.dr-bob.org/babble/20050527/msgs/504845.html