Posted by Sarah T. on April 25, 2005, at 2:16:23
In reply to Re: Effects of Selegiline's amphetamine metabolites? » Sarah T., posted by cache-monkey on April 24, 2005, at 23:05:04
Hi cache-monkey. All I know about buproprion is that I was on it for a long time, and I had terrible insomnia, high blood pressure, palpitations and anxiety, in spite of what the drug company literature advertised at that time. I also know that, among other things, bupropion is a potent inhibitor of the 2D6 liver enzyme, and that hydroxybupropion is a substrate of that same enzyme. In the other words, the drug inhibits its own metabolism! If you happen to have a fairly robust version of that enzyme in your liver, then I guess you can handle the medicine well. On the other hand, if you're like me (a poor metabolizer), then taking a drug that inhibits its own metabolism is going to be very unpleasant, if not downright dangerous.
poster:Sarah T.
thread:487473
URL: http://www.dr-bob.org/babble/20050423/msgs/489120.html