Posted by shoebox on January 24, 2005, at 11:57:41
In reply to Re: REM sleep/Prozac/PLMD?, posted by Kenny Koala on January 24, 2005, at 11:16:28
> Reduced or nil Stage 4 sleep is a side effect of all SSRI's & Effexor, not just Prozac. Excess agonism of Serotonin 2A receptors(5-HT2A) by the increase in Serotonin levels is the cause. The cure is rather simple, take a low doseage of something that is a 5-HT2A antagonist. Amitriptyline, Doxepin, Remeron, Trazodone or Trimipramine would be my first choices. Most antimigraine & antipsychotic drugs are 5-HT2A antagonists too. 5-HT2A receptors also control other body functions such as temperature control, anxiety & orgasm. [Yeah, tell me about it!! :-/]Thanks for responding, Kenny. Interesting stuff. Now I wonder why:
a. the sleep clinic doc would be unaware of SSRIs' effects on REM sleep (he was no dummy). He didn't even seem to factor it in at all, much less point to it as the main culprit.
b. am I suddenly having this sleep problem now, after everything was running so smoothly for so long? (I know, I know...strictly rhetorical)
Elavil and trazodone make me dopey, so those are out. I've never tried the others. Arrrgghh. And here I was down to only TWO meds! I don't want to start throwing things at the problem and messing with my current combination, which is the best I've ever had after 12 years drug-hopping. No way am I giving that up.
Anybody had success with something *other than* klonopin for PLMD or Restless Leg?
poster:shoebox
thread:446722
URL: http://www.dr-bob.org/babble/20050124/msgs/446781.html