Posted by mattdds on December 19, 2004, at 8:50:07
In reply to Re: Delayed Sleep Phase Syndrome? » mattdds, posted by Larry Hoover on December 19, 2004, at 8:14:04
>>Ya, but dose may be an issue, too. Too much melatonin can do as you describe. Individual differences in dose-responsivity are such that the typical 3 mg tablet can be far in excess of your individual needs. Saturation of the melatonin receptors actually shuts some of them off, and inhibits sleep induction.
Sorry, I'm American, and more is always better.
Wow, hadn't thought of that. This is interesting because I was taking my dad's horse pills (2mg) when I trialed melatonin. Maybe I'll give it another go at a lower dose. Perhaps 0.5mg 6h before bedtime? I'm not even sure what "sizes" they come in.
I remember thinking before taking them that melatonin is released in extremely tiny amounts (measured in nanograms, no?) by the pineal gland, and that 2mg seemed like a whopping dose.
Sounds similar to what supposedly happens during initial SSRI therapy. Autoreceptor stimulation?
Cool stuff Larry, thanks! And hey, good to see you posting here too. I know from my lurking days, that you were missed by many.
Regards,
Matt
poster:mattdds
thread:431185
URL: http://www.dr-bob.org/babble/20041217/msgs/431583.html