Posted by Larry Hoover on December 16, 2004, at 8:07:35
In reply to Re: Gene Linked To Treatment-Resistant Depression » SLS, posted by ed_uk on December 16, 2004, at 7:37:28
> Hi Scott,
>
> I wonder whether taking an SSRI + L-Tryptophan might be an effective treatment strategy for people with the abnormal tryptophan hydroxylase gene who had failed to respond to SSRIs alone.
>
> Ed.As the enzyme has some activity, there are two ways to ensure optimal function of the existing enzyme. One is to ensure ample supplies of the substrate, as the velocity of the enzyme (to saturation) is a function of substrate concentration. The other is to ensure adequate cofactor concentration, which in this case, is tetrahydrobiopterin (BH4). A drug may be quite unnecessary.
Lar
poster:Larry Hoover
thread:430192
URL: http://www.dr-bob.org/babble/20041211/msgs/430210.html