Posted by pablo1 on November 28, 2004, at 16:44:02
In reply to Re: Why arnt there more --Linkadge? » banga, posted by Larry Hoover on November 27, 2004, at 8:17:53
Can someone explain the results of this. I searched any flavor of dopamine in humans using dopamine% as a wildcard and got almost 2,000 results. I crunched that into excel to sort and there are usually several records for each med, some with very different results. I assume the Ki (nM) column is the important one, indicating the effect the drug has on dopamine. I have no idea what Ki (nM) means, is that agonism or reuptake inhibition. In the recptor column they have either the specific D1, D2, etc or 'Dopamine Transporter' or even some odd ones like 'Dopamine2-like'. Does the transporter comment imply reuptake inhibition?
some familiar meds results:
DOPAMINE D3 Amisulpride 2
DOPAMINE D2 Amisulpride 1
(but I checked not human tests & got huge numbers)
Dopamine Transporter Amphetamine,(+) 25
(not very high?)
Dopamine Transporter d-AMPHETAMINE 21,000
DOPAMINE D1 d-AMPHETAMINE 10,000
DOPAMINE D2 d-AMPHETAMINE 10,000
DOPAMINE D3 d-AMPHETAMINE 10,000
Dopamine Transporter d-AMPHETAMINE 190
Dopamine Transporter d-AMPHETAMINE 116
DOPAMINE D1 Ephedrine,(-) 10,000
DOPAMINE D2 Ephedrine,(-) 10,000
DOPAMINE D5 Ephedrine,(-) 10,000
DOPAMINE D3 Ephedrine,(-) 10,000
Dopamine Transporter Ephedrine,(-) 236
DOPAMINE D5 MDMA 10,000
DOPAMINE D3 MDMA 10,000
DOPAMINE D2 MDMA 10,000
DOPAMINE D1 MDMA 10,000
Dopamine Transporter MDMA 10,000
DOPAMINE D1 MDMA, R(-) 10,000
DOPAMINE D2 MDMA, R(-) 10,000
DOPAMINE D1 METHYLPHENIDATE 10,000
DOPAMINE D2 METHYLPHENIDATE 10,000
Dopamine Transporter METHYLPHENIDATE 50
Dopamine Transporter METHYLPHENIDATE 42
Dopamine Transporter METHYLPHENIDATE 34
Dopamine Transporter METHYLPHENIDATE 21
DOPAMINE D1 METHAMPHETAMINE (+) 10,000
DOPAMINE D2 METHAMPHETAMINE (+) 10,000
Dopamine Transporter METHAMPHETAMINE (+) 25
DOPAMINE D2 BUPROPION 35,000
Dopamine Transporter BUPROPION 1,800
Dopamine Transporter BUPROPION 950
Dopamine Transporter BUPROPION 784
Dopamine Transporter BUPROPION 562
(wide range of results)
DOPAMINE D3 COCAINE 10,000
DOPAMINE D2 COCAINE 10,000
DOPAMINE D5 COCAINE 10,000
DOPAMINE D1 COCAINE 10,000
Dopamine Transporter COCAINE 743
Dopamine Transporter COCAINE 469
Dopamine Transporter COCAINE 331
Dopamine Transporter COCAINE 240
Dopamine Transporter COCAINE 214
DOPAMINE D2 Venlafaxine 35,000
Dopamine Transporter Venlafaxine 10,000
DOPAMINE D2 Venlafaxine 10,000
DOPAMINE D3 Venlafaxine 10,000
DOPAMINE D2 Venlafaxine 10,000
Dopamine Transporter Venlafaxine 7,647So it seems the numbers are all over the place. Can these numbers just be looked at simply or you'd really need to go track down each study to figure out the relevance?
>
> According to this database, linkange is quite correct:
> http://kidb.cwru.edu/pdsp.php
>
> Put the generic name of the drug in the "test ligand" field.
>
> Sertraline has higher affinity at the D2 receptor and at the dopamine transporter than does bupropion. Lower numbers are higher affinities.
>
> Lar
poster:pablo1
thread:420713
URL: http://www.dr-bob.org/babble/20041128/msgs/421458.html