Posted by cybercafe on September 9, 2004, at 0:35:02
In reply to Re: Switch from Nardil to Parnate-KingVultan How is it » bluebird, posted by King Vultan on September 6, 2004, at 23:14:07
> I've been on 30 mg/day for six days now and was on 20 mg/day for a week before that. Parnate does seem to have fewer side effects than Nardil, which is what the literature indicates. My BP has gone down some but not as much as on Nardil, and more importantly, my pulse has remained close to normal instead of being in the 50's like it was on Nardil. I am not suffering the weakness/dizziness spells that were a constant nuisance on Nardil, and I seem able to exercise at a normal rate rather than being limited as I was on Nardil.
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> I found Parnate moderately stimulating at first, but I already seem to have adjusted to this. However, I am suffering insomnia just as I did on Nardil--no big surprise there. Moodwise, I felt effects within two or three days of each dosage increase, so what they say about this stuff being fast acting seems to be true also. I must admit to having retreated into moderate but not severe depression much of the last three days, but as I've indicated in other posts, I may have an issue with hypersensitive presynaptic dopamine autoreceptors. If so, I may have to suffer a bit while those receptors (hopefully) downregulate. Inspite of this, I have also noticed a big cognitive improvement, and for me, Parnate is clearly superior to Nardil in things like reading comprehension. This is probably no big surprise, as I do have ADD symptoms, and there doesn't seem to be much question that Parnate is relatively dopaminergic.
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> Todd
you may not notice this..... but i found, and my doc agreed, that the initial stimulating effects of parnate may diminish overtime while the MAOI antidepressant effects take a bit longer to start to workfor me i didn't really notice a major improvement until 12 - 16 weeks the second time around (took longer the second time around) .... but it's hard to say, because I had to combine parnate with actually getting out there and doing things for it to work (i know that sounds obvious ... but it is actually rather insidious.. you just don't expect previously too boring or too difficult things to be fun and when you find out that they are -- in my experience anyways -- that's when your depression really lifts .... i think you could wait around forever and not get more than say 50% relief unless you really start living out your dreams)
poster:cybercafe
thread:387181
URL: http://www.dr-bob.org/babble/20040904/msgs/388501.html