Posted by Shawn. T. on July 7, 2004, at 18:38:27
In reply to What exactly does Neurontin do????, posted by Robz on July 7, 2004, at 8:43:02
Neurontin binds to the alpha(2)delta-1 and alpha(2)delta-2 regulatory subunits of voltage-gated calcium channels; however, it does not bind with high affinity to alpha(2)delta-3 or alpha(2)delta-4 subunits. As a result, the functionality of different types of voltage-gated calcium channels is altered by the drug; the channels are typically inhibited. In neuron terminals, the influx of calcium ions though voltage-gated calcium channels is a step involved in the release of neurotransmitters; when the action potential reaches the terminal, the channels open as a result of the change in electrical potential. Neurontin can therefore reduce the release of several neurotransmitters as a result of its interaction with certain regulatory subunits of voltage-gated calcium channels. Other mechanisms of action have been proposed, but they are controversial and not yet well-supported in my opinion.
Shawn
poster:Shawn. T.
thread:363684
URL: http://www.dr-bob.org/babble/20040704/msgs/363820.html