Posted by zeugma on July 6, 2004, at 10:35:10
In reply to Re: Glenmullen - How reliable are his methods?, posted by linkadge on July 6, 2004, at 9:39:22
> What scares me is the fact that this guy did not publish the serotonin receptor corkscrew article, he was just referencing it. What he is saying is somewhat sound. We know that people who use methamphetamine over time show extensive nerotoxicity why couldn't this extend to other stimulants.
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> I agree that using SSRI's increases neurogenesis, this is because activating the 5ht1a receptor spurs downstream cell devision. But what this new reserch suggests is that the receptors themselves are getting destroyed. I don't think this is impossible to believe. Perhaps it is just the depression but since being on SSRI's my concentration and grades have slowly plummeted. I don't read books anymore cause I cannot understand what I am reading, my brain buzzes etc. These are symptoms that I never had, even when I was depressed.
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> I am scared because everybody I know who has discontinued an SSRI after using it 5+ years has had to return to it. Everybody I know who has discontinued and SSRI says that they're just not the same. Perhaps corkscrewed receptors is why some degree of poop out happens to almost all SSRI users.
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> I don't mean to cause panic but I just don't know how to get better.
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> Linkadge
>i wonder if clomipramine is as prone to poop-out as SSRI's. It has been around since the '50's and I have not heard any reports of it corkscrewing receptors or anything.
Cheney endorses doxepin, a TCA, on the page linked to his article.
I know the 5-HT system is complicated, and there are fewer metabolic pathways for the degradation of 5-HT than there are for NE. I think that the concomitant use of serotonin antagonists (trazodone, mirtazapine, etc.) probably helps preserve the serotonin/dopamine balance, which is a major theme of Glenmullen's book, and this must be a good thing for serotonin receptors. (Glenmullen doesn't mention this, by the way; he is mostly interested in alarmism.) Buspirone is another option, because it is a serotonin modulator (it either lowers or raises 5-HT levels based on the amount of 5-HT in the system, and also increases DA and NE levels).
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poster:zeugma
thread:363268
URL: http://www.dr-bob.org/babble/20040704/msgs/363453.html