Posted by Sad Panda on May 29, 2004, at 3:51:30
In reply to Re: Chemist: Remeron taken with MAOI, posted by Random987 on May 29, 2004, at 3:10:37
> Thanks,
>
> Given the study I posted, it appears that there is less then 1/2 of one percent of having a problem if you take Remeron and Deprneyl....
>
>Theoretically, Remeron raises serotonin levels, but in reality it is an insignificant amount, so serotonin syndrome is very remote & probably only likely to occur to people who are extremely med sensitive. Remeron also raises NE at high doseages via Alpha-2 NE antagonism, but retains enough Alpha-1 NE antagonism to keep blood pressure down.
If you want a sedative AD to combine with an MAOI, I believe that low dose doxepin would be a good choice or high dose nortriptyline if you are looking to for some additional AD effect. These two are both NRI which would block tyramine from being taken up & they are 5-HT2A blockers which is believed to be the mechanism for reversing serotonin syndrome.
Also, low dose or high dose Deprenyl are two differnt things. Low dose it's a MAO-B inhibitor, which means serotonin or NE are not raised, high dose it becomes non-selective & it's said that it closely resembles Parnate.
Cheers,
Panda.
poster:Sad Panda
thread:342638
URL: http://www.dr-bob.org/babble/20040527/msgs/351769.html