Posted by Francesco on January 9, 2004, at 17:46:06
In reply to Re: anyone had success with desipramine for adhd ? , posted by zeugma on January 9, 2004, at 16:24:57
> remeron is actually antiserotonergetic. It blocks serotonin 2 and 3 receptors potently.
>
> A little advertised fact is that many antidepressants are better described as "antiserotonergetic" than "serotonergetic." Many are both at once, like amitriptyline, and it is reasonable to think that this is partly responsible for the fact that no single AD seems more effective over a wide range than amitrip.This beats me : ) I have never heard of that an antiserotoninergic med could work as an antidepressant. May you explain me better this point ? (pardon me for my naive knoledge of pharmacology and of english too ;-)
> If SRI's make you moody then maybe Remeron would help, but desipramine by itself shouldn't set off serotonin-related problems.
Mumble mumble. So my doctor thinks something like I have too much serotonin circulating in my system ? Is this what you mean by 'serotonin-related problems' ?
> I've read reports of ADHD adults responding favorably to a very low dose of desipramine.
I have read a lot of reports too and this is the reason why I'm on it. Even if it's only the my first day I can say I'm having good signs. It doesn't make me hostile like all the other meds I've tried and this is a good starting point for me since I don't want to hurt other people anymore.
> Did imipramine cause a lot of side effects? Desipramine is supposed to cause much less in the way of s/e, and to be, as your pdoc seems to worry, a lot more activating.
I can't remember bad physical side effects with Imipramine but I was on a very low dose for few days. The main reason for which I quit it was the nervousness and the hostileness mentioned above. There was also constipation I think, but if I have to take TCAs I have to cope with it, I suppose.
On the other hand nortriptyline felt OK the first day, and Strattera felt very alerting, and I continue to take both drugs with great success and minimal side effects.You should trust your instincts when it comes to these drugs.
Thanks for sharing, the last it seems to me a very good suggestion. So now you are on nortriptyline and Strattera, is it right ? What about side-effects of the combo ?
poster:Francesco
thread:298482
URL: http://www.dr-bob.org/babble/20040109/msgs/298791.html