Posted by zeugma on October 11, 2003, at 9:09:52
In reply to Francesco! More on Tricyclics! » francesco, posted by DSCH on October 9, 2003, at 15:38:10
> > >I'm not basing this on theory, I am just >thinking that this is direct evidence we should >leave your serotonergic neurons alone! ;-)
> >
> > I do think so. That's the reason why I would prefer desipramine rather than imipramine (it's less serotoninergic than Anafranil, anyhow it's serotoninergic). Of course I'm not going to tell the deep reason to my new p-doc ;-)
> >
> > About yohimbe and thinking about sex ... have you considered OCD ? ;-) (of course I'm kidding !!! : )
> >
> > bye, I'll stay out for a couple of days to see my PHD tutor in Parma ... hope he won't kick my a** ... I have ADHD, I'm disabled !
>
> I hope your meeting has gone well. I can remember how frustrated by thesis advisors got with me. They could tell how much knowledge and creativity I could bring to bear on problems, but I lacked the will and focus to sustain the work in the lab. Anyway, even improved I have to admit I am more of an idea guy than an experimentalist. I need to find something that suits me and brings in some income. :-/
>
> Anyway... a little tidbit of information for you regarding tricyclics I came across as I was looking for stuff on herbals...
>
> Nortriptyline is weighted more towards serotonin reuptake inhibition than it is norepinepherine. Unfortunately the manner in which this book sites references is very clumsy; if you wish I can provide them for you sometime.
>
> Imipramine is possibily a step in the right direction (NE > 5-HT), while desipramine appears to be the most NE targeted tricyclic (NE >> 5-HT).
>
>
Hi, sorry to jump into this conversation (and I am a pretty rank beginner when it comes to the subtleties of neurochemistry and such :)) but everything I have read suggests the the rank order for NE vs. 5-HT affinities of tricyclics is desipramine > nortriptyline > imipramine > amitriptyline. Of course, this is complicated by the fact that the tertiary amines are metabolized to noradrenergic secondary amines; this is true of clomipramine, as well, which the impressive new "Manual of Clinical Psychopharmacology" describes as possibly the only true serotonergic among the TCA's. (Very likely this is true for fast metabolizers of the tertiary amines; however, there sems to be wide variability in rates of absorption etc.; the secondary amines have a simpler metabolism, which is another big advantage for this latter class.)See this link for more details:
http://jpet.aspetjournals.org/cgi/content/full/283/3/1305
poster:zeugma
thread:260422
URL: http://www.dr-bob.org/babble/20031010/msgs/268284.html