Posted by Larry Hoover on October 4, 2003, at 10:19:11
In reply to Ask Larry Hoover, or-?, posted by EscherDementian on October 3, 2003, at 13:19:51
> > Hmmm... that's a really good question. Hope someone here has an answer.
>
> >>A curiosity:
> >>If (Do?) different SSRIs selectively inhibit seratonin reuptake differently from each other, what would be the effect of alternating between two (say Zoloft and Lexapro) every other day?
> >>Would they work synergistically? Or parallel? Or conflict?
> >>Would there be an added benefit?
> >>
> >>EscherI'll give you my opinion....because of the relatively long half-life of SSRIs, I don't think it would much matter that you alternate days. It would be the same as taking both at the same time, with all the attendant risk of additive effects like serotonin syndrome. Of course, total dose would be an issue.
I don't think you'd get the benefits of one plus the benefits of the other. I think you'd get the adverse effects of one plus the adverse effects of the other. But that's just my opinion.
Lar
poster:Larry Hoover
thread:263877
URL: http://www.dr-bob.org/babble/20031004/msgs/265497.html