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Re: Cuticle destruction - try selegiline

Posted by elleff on June 24, 2003, at 18:42:51

In reply to Re: Cuticle destruction - try selegiline » elleff, posted by jemma on June 24, 2003, at 10:22:43

> Hi elleff -
>
> Did you find that at 15 mg of selegiline you had to follow an MAOI diet? I considered trying 15 mg, but held back at 10 to avoid the diet.
>
> - Jemma

Hi Jemma

No, I don't follow the MAOI diet & have had no trouble eating cheese etc. I should point out however that I do weigh about 100kg and am about 187cm - ie not a small fellow - so on a mg per kg basis 15mg for me might be equivalent to 10mg for a smaller person. Whilst on Parnate years ago I did experience a hypertensive reaction (to someone's homemade chocolate sauce with nuts which I suspect hadn't been stored too carefully), so I am familiar with the symptoms of such a reaction. Naturally I am careful, even on this dose of Selegiline, to avoid all medications (including pseudoephedrine) that could cause hypertensive reactions.

Another point that I should have mentioned in my earlier post is that I have been trialing, on and off, the addition of l- and dl-phenylalanine in varying doses to the selegiline. Several studies have suggested that such combinations have antidepressant effects, and various people have speculated that their might be also be benefits as regards ADD symptoms too. For what it's worth my impression is that l-phenylalanine in the range 500 - 1000mg per day (taken along with a multivitamin containing 50mg of Vit B6) on an empty stomach first thing in the morning probably enhances the effect of Selegiline. dl-phenylalanine is probably similarly useful, however I suspect it is somewhat sedating, presumably because of the inhibiting effect of d-phenylalanine on enkephalinase.

regards

elleff


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