Posted by Larry Hoover on May 23, 2003, at 12:07:34
In reply to Re: here are links to graphics of the structures » Larry Hoover, posted by Ron Hill on May 23, 2003, at 11:05:37
> Larry,
>
> Thanks for the links. It was reassuring to see that the mental pictures I had formulated for the structures of these compounds based on your written descriptions were the same as the drawings in the links.A-hah! You *were* paying attention in o-chem! You just don't want to admit the true depth of your geekiness. <smirk>
> I am amazed how well 250 mg/day of nicotinic acid treats my irritability. I’m currently splitting it into two 125 mg doses taken morning and late afternoon. I have always been under the impression that the B’s should be taken together as a complex and taken shortly after a meal. However, I’m finding benefit from taking nicotinic acid in isolation and on an empty stomach. Any thoughts on this issue?
The B-complex concept is a good rule of thumb, simply because an abundance of some B's will mask deficiencies in others, until possibly permanent adverse effects appear.
So long as you get the other B's along the way (actually, a weekly running average concept is useful here), you're OK. If you perceive your use of niacinamide as direct treatment for an idiosyncratic biochemical quirk, it makes perfect sense, non?
> I sure hope that the efficacy continues indefinitely, and I think it will because, like you said previously, it does not build up in the body. I'll write more details in a post to Johnj subsequently in this thread. Thanks again Lar.I see no reason for the benefit to diminish, unless there happens to be some sort of change in receptor regulation. I'm stretching, to even suggest that.
> How’re your CFS symptoms doing lately? Is Enada NADH still providing some amount of beneficial effect? If so, roughly how many milligrams do you take per week? Still taking the sublingual formulation?
>
> -- RonI'm using the Enada purely on a gut-level sense of need, intuitive. That seems to work for me. Initially, I think I got my NADH saturation up, and now it just needs occasional tweaking. There's an alternative explanation than NADH deficiency, per se. It is possible that there is another substance that accumulates unless there is more than enough NADH to go around. The "other stuff" excess might lead to symptoms.
I'd say I'm using 5 mg/week, on a running average basis. Despite a gruelling series of trips over the last four weeks, I'm not feeling even the slightest glimmer of imminent decline. More typically, by the last week of my work session, I'm noticeably sliding.
My pdoc had nothing to offer me in the way of treatment for the CFS (possible drug strategies were not covered by my limited disability drug benefits), and no possible referrals to specialists were available (they're already swamped with patients). He was most interested in my anecdotal experience, and recorded all the details. I suspect he's going to look into it, and possibly use the idea in his practice. My GP (general practitioner) doctor has already made use of it.
Lar
poster:Larry Hoover
thread:223158
URL: http://www.dr-bob.org/babble/20030520/msgs/228600.html