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Re: Is Zyprexa a serotonin agonist or antagonist? » cybercafe

Posted by zeugma on March 30, 2003, at 15:53:10

In reply to Re: Is Zyprexa a serotonin agonist or antagonist?, posted by cybercafe on March 30, 2003, at 0:21:18

> > I would be very wary of mixing an AP, even a new atypical one, with an MAOI. The side effects of either are potentially so serious- hypertensive crisis and serotonin syndrome for the one, irreversible TD for the other- that even if not absolutely contraindicated (I have no idea), it's just asking for neurological disaster.
>
> i felt great on parnate + zyprexa ... i know they are both serious medications... but i don't see a reason to believe that the risks increase when they are taken together
>
That's good to hear. I believe you have been dx with ADD? Was the Parnate helpful for this disorder?

> > Seems that 5HT2A by itself just helps with sleep rhythms (isn't that what ritanserin is for?) This can be very helpful for depressed people but I doubt it's enough to remit depression by itself.
>
> i don't know anything about ritanserin ... where did you hear about it's use in sleep rhythms?
>

Ritanserin increases slow-wave sleep: http://link.springer-ny.com/link/service/journals/00213/contents/00/00633/s002130000633cl

It appears from this study that 5HT-2A antagonism won't help with anxiety or depression but can help with specific sleep problems.


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