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Serotonergic meds and dopamine

Posted by Caleb462 on March 30, 2003, at 15:51:23

In reply to Re: question about dopamine, posted by jonh kimble on March 30, 2003, at 13:43:13

What happens when one takes SSRIs, SNRIs, or other meds that increase serotonin transmission, is that the brain's 5-HT2c receptors are being overactivated. One of the functions of the 5-HT2c receptor is to reduce dopamine transmission in some areas of the brain.

So, basically, serotonergic meds cause extensive 5-HT2c activation and therefore decrease dopamine transmission.

However, this should be less of an issue with Prozac, as Prozac is a 5-HT2c antagonist.


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URL: http://www.dr-bob.org/babble/20030329/msgs/214488.html