Re: abilify...why is it causing anxiety in some folks?

Posted by Shawn. T. on January 14, 2003, at 23:03:36

In reply to Re: abilify...why is it causing anxiety in some folks?, posted by neetie on January 8, 2003, at 23:10:22

I think that I should clarify this somewhat; neetie's explanation is basically correct, though. I believe that Abilify's actions as an antagonist (blocker) at dopamine D2 receptors in the ventral tegmentum (part of the mesolimbic pathway) are responsible for its pro- anxiety effects. Because of this effect, dopamine is increased in the nucleus accumbens septum; enhancement of dopamine's effects on D2 receptors in this region causes anxiety as well.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7969883&dopt=Abstract
Shawn

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abilify...why is it causing anxiety in some folks? highanxiety 1/7/03
Re: abilify...why is it causing anxiety in some folks? neetie 1/8/03
thanks so much for the explanation..was wondering! highanxiety 1/9/03
Re: abilify...why is it causing anxiety in some folks? Shawn. T. 1/14/03
Re: abilify...why is it causing anxiety in some folks? cybercafe 1/15/03

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poster:Shawn. T. thread:134883
URL: http://www.dr-bob.org/babble/20030113/msgs/135908.html