Posted by Peter on January 7, 2003, at 16:42:12
Well, it's been a very tough few weeks. Last week, when I was still taking 50mg zoloft and 50mg lamictal, I started getting very symptomatic-depressed, anxious, antisocial,etc.. my pdoc said it probably had to do with synergistic serotonergic activity between the lamictal and zoloft, so he had me decrease the zoloft every 4 days by 12.5mg until I wasn't on it anymore. So, I basically came off of 50mg zoloft in about 1 week. Side effects? crying spells, extreme mood swings, electric shock sensations down my arms and legs, weakness, migraines, and pretty much just a complete inability to function. In my desperation, I started proposing to him that we start me up on a TCA since SSRI's don't sit well with me. But he kept saying I should just push on through, as the lamictal could really potentially end up being the grand-slam drug for me after all these years. Meanwhile, he reduced the depakote further from 500mg to 250mg. So I've been a mess; but I'm just now beginning to feel a little better.
I'm just wondering: does anyone know what kind of serotonergic activity lamictal promotes that causes it to be considered by many to have such marked antidepressant properties? I mean, does it increase serotonin or block its reuptake? Does it affect other neurotransmitters involved in depression and anxiety (NE, DP, etc.). If so, how? I can't seem to find any informative links on the web concerning this subject, and I'd love to be informed since my pdoc thinks lamictal could replace AD's AND AC's. Thanks in advance,
Peter
poster:Peter
thread:134864
URL: http://www.dr-bob.org/babble/20030106/msgs/134864.html