Posted by Shawn. T. on August 7, 2002, at 1:53:40
In reply to Tremendous strides with ondansetron , posted by ryan_s on August 5, 2002, at 21:37:01
Other selective 5-HT3 antagonists are granisetron, tropisetron, and hydrodolasetron. I find tropisetron to be the most interesting one of the bunch (2 to 5mg hint hint). You would probably be able to give the people curious about substance p antagonists a bit of knowledge (5-HT3 antagonists may be better in my opinion, but I can't say for sure). I'd like to hear from someone that has combined one of these drugs with Wellbutrin; I am wondering about how that might work out. Note that I'm primarily interested in these drugs for their pain relieving effects (some people say antidepressants are actually analgesics; I would agree).
http://nootropics.com/tropisetron/index.html
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=28908356
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=24286515
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=29152513
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=28908361
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=11338441
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=23342224
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=16309414
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=10633193
"The absolute reduction in pain-score was -13.5% for 5 mg tropisetron, -13.0% for 10 mg tropisetron, and -6.3% for placebo (p<0.05). The effects of 15 mg tropisetron were similar to placebo, thus suggesting a bell-shaped dose-response curve."
I'd like to figure this out. 5-HT3 receptors are confusing, however, so I'm not sure it will be an easy puzzle to put together. I am super curious about how that information might apply to Remeron; I am constantly telling people that they're taking too much. I really believe that 5-HT3 antagonists are terrific drugs. I disagree with the kitchen sink statement about Remeron; I find that it is a well thought out drug. What's not well thought out is the dosage recommendations. 7.5mg/day works well for me, and I was even considering lowering the dosage just to see what happens. I burned one of my fingers on a hot oven coil and felt a glimpse of slight pain for about a second. I can bite hard into my arm (for science, not mutilation), leaving a mark, and feel no pain at all. Stubbing my toe isn't nearly as bad as it used to be, etc etc. I'll go deeply into detail on why 5-HT2 and 5-HT3 antagonists relieve pain if anyone wants me to...
Shawn
poster:Shawn. T.
thread:115356
URL: http://www.dr-bob.org/babble/20020731/msgs/115511.html