Posted by pharmrep on July 31, 2002, at 21:49:05
In reply to Re: Captain Mitch and the downers, posted by pharmrep on July 31, 2002, at 21:30:49
oops..forgot to retitle the last one..sorry. Kate, I like your trust note, I will continue to earn yours.
You said you like Meta-regression analysis, well try this. Nick Freemantle British Journal of Psych. 2000, 177, 292-302
(It is sponsored by Wyeth Labs but backfired) ultimately it is a compilation of 105 studies/11000+ patients to see if hitting
other receptor sites other than serotonin is better (ie Effexor hitting Norepinephrine at above 150mg)...it says "This analysis does not provide evidence that anti-
depressants acting at more than one pharmacological site differ in efficacy from drugs selective for serotonin reuptake in the
treatment for major depression". Even though Wyeth sponsored, he goes on to say that "dual action" has "become a marketing concept
for a number of antidepressants, and this study raises the question as to whether it has a legitimate scientific basis, in considering
mechanisms behind antidepressant efficacy." Again...wow. Anyway, I wanted to show this study to you so you can see that Dr's dont care
who is paying them...they just run the tests, they wont destroy their credibility for a paycheck.
poster:pharmrep
thread:109458
URL: http://www.dr-bob.org/babble/20020731/msgs/114710.html