Posted by cybercafe on July 26, 2002, at 0:53:18
In reply to Re: downregulation??, posted by Shawn. T. on July 25, 2002, at 18:40:39
okay i'm really sleepy so i'm going to have to fly through this
> I believe it is a combination of two molecules which can fit another molecule into it.
hmmm... okay, may i ask where you arrived at that conclusion from
>functional coupling to an inward rectifying K+ channel. Rectifying would seem to be used in the electrical context here, so I believe it means to convert alternating current into direct current.
rectifying means current is only allowed in one direction... inward rectifying means, K+ ions are only allowed to travel inward ... probably due to some active transport mechanism (as diffusion would cause it to flow outward)
... there are some excellent discussions on this and much more in Kaplan and Sadock's Comprehensive Textbook of Psychiatry (Not Synopsis of Psychiatry)> There was a thread earlier about GHB; I'll try to apply what I've said to it. There have been arguments made that GHB may actually be a
if i could actually get my hands on GHB, i do have some guinea pigs awaiting
>pain regulation. For instance, 5-HT3 may be negatively coupled with GABAb. GABAb may be able to inhibit substance P release. So when 5-HT3 is activated, substance P is released. A 5-HT3 antagonist like Remeron should therefore inhibit substance P release, which it has been shown to
it probably depends on what brain circuit you are talking about...
for example, i have been concerned with the nucleus accumbens, and i know that 5HT3 has positive effects on the release of dopamine, and substance P may have negative effects.... therefore i wonder if a 5HT3 agonist may display substance P antagonism .... but that would be a jump in logic.. and i see no reason to make jumps in logic when there is solid information out there ... or at least until i have run out of solid information to go on :)
cybercafe
poster:cybercafe
thread:113408
URL: http://www.dr-bob.org/babble/20020725/msgs/113761.html