Posted by Shawn. T. on July 13, 2002, at 16:39:52
In reply to Re: More more more antidepressant theory, posted by cybercafe on July 13, 2002, at 0:20:54
Those are some challenging questions.
With regards to linking intelligence to depressive symptoms; I actually thought that you told me that! I will definitely look into this more. Especially noteworthy is the high rates of depressive symptoms in child prodigies. That may just be because of social reasons. I don't know how I came up with that, strange. I would argue that it is to everyone's benefit that we research different topics; you are certainly not a close minded person.The adrenal gland is responsible for cortisol production. It also produces aldosterone and testosterone.
"Corticosteroids may affect brain function through two general mechanisms, interaction with the genome and interaction with cell membranes (9, 10). Corticosteroids freely cross neuronal cell membranes and, in neurons containing specific cytoplasmic steroid receptors, translocate as a steroid-receptor complex to the cell nucleus (9, 35). There, the complex binds to chromatin and regulates transcription of specific genes."
See the following for the best information you'll find on cortisol on the net
http://www.psychosomaticmedicine.org/cgi/content/full/61/5/698So 5-HT2 actions are related to every neurotransmitter implicated in depression!
I suggest that Wellbutrin was the first step in curtailing my drug abuse. I used it to quit smoking. You'd probably be able to explain that better than I could. Next, the addition of Remeron effectively reduced my opiate cravings. As for why I don't crave marijuana, I'll get back to you. I can figure it out. Also, I now believe that hallucinogens will be ineffective on me (see my discussion on schizophrenia).
As for the opiate cravings, see
http://opioids.com/naloxone/depcrf.html
and
http://www4.infotrieve.com/newmedline/detail.asp?NameID=11931344&loggedusing=M&Session=98474&SearchQuery=mirtazapine+AND+dopamine&count=12For more on adenylyl cyclase and some good knowledge on caffeine (I quit consuming it after reading this), see
http://www.madsci.org/posts/archives/feb2000/950223638.Cb.r.html
"Up regulation means... compensating by increasing the number of neuroreceptors? ... but if you use an agonist.. and cause the neuron to fire more than usual.. wouldn't it adapt .. compensate.. by decreasing the number of neuroreceptors?"
-Yes, I believe you are probably correct. A possible poopout theory? I'll do some more reading on this.
"but then if you're wrong, you could die from serotonin syndrome or the opposite :)"
-Please don't take them at the same time! Take the SSRI say an hour or two after you have completely come down (that would signal a decrease in serotonin transmission).I'll get back to you on the glutamate with relation to 5-HT6. Increasing glutamate levels is the single most effective means of improving cognition in my opinion (neurotransmission is sped up). I'll have to read about dopamine's effects on glutamate levels.
I described why I don't like ritanserin elsewhere in this forum.
poster:Shawn. T.
thread:111957
URL: http://www.dr-bob.org/babble/20020709/msgs/112239.html