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Re: 'Sulpiride' and anxiety

Posted by tex1 on May 4, 2002, at 7:12:30

In reply to Re: 'Sulpiride' and anxiety » Ken, posted by JahL on May 3, 2002, at 20:19:33


> Hi John. Contrary to the claims of an earlier poster, both Amisulpride & Sulpiride most certainly do possess anxiolytic properties; if they didn't they wouldn't be regularly prescribed for anxiety (& particularly s. phobia) by, amongst others, the staff of the Maudsley hospital (the UK's pre-eminent, or at least most famous, psych unit.). I've seen a few pdocs & profs there over the years and all of them, w/o exception, viewed both drugs as 'effective' (like all drugs, only for certain individuals) second or third line agents for anxiety, and not depression (they are used for that purpose on the Continent but the consensus here seems to be that the AD effect, when apparent, is fairly mild).
>
> I was first prescribed Sulpiride (indication: anxiety) by a provincial pdoc so, whilst it may not be a commonly used drug, its anxiolytic properties are recognised beyond the confines of teaching hospitals.
>
> Regards,
> J.

The anti-anxiety effects does exist, but not at the dosage reccomended for depression (as here in Europe is prescriped mostly for this). The amisulpride dosage is usually 50 mg day in this case. Over this dosage you're surely going to feel an anti anxiety effect due to the dopaminergic receptors blockage. So it mostly looks like an "anergic" and "ataraxia" effect than a pure anti-anxiety effect.

Best luck

Tex


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