Posted by fachad on April 16, 2002, at 16:19:19
In reply to Re: New Antidepressants in Development?, posted by geno on April 16, 2002, at 15:12:30
Both desipramine and reboxetine are SNRIs.
Desipramine is far more potent at blocking NE reuptake than Reboxetine. The 1/K values are 120 for desipramine and only 14 for reboxetine. So desipramine is more than 8 times more potent than reboxetine. For comparison Elavil is 3, Paxil is 2.5, and Prozac is 0.5.
Reboxetine is also less selective than desipramine. The ratio of selectivity NE:5-HT is 21 for desipramine, and it is 8 for reboxetine.
I don't really know what all the hype is about reboxetine, because it is less potent and less selective than desipramine. It is, however, more profitable because it is still under patient. That probably explains the hype.
> From what i understand, isnt reboxatine similar to the tca desipramine, a selective norepinephrine medication?? or i could be wrong.
> geno
poster:fachad
thread:103083
URL: http://www.dr-bob.org/babble/20020416/msgs/103254.html