Posted by johnX2 on March 13, 2002, at 16:14:28
Have you seen this Naltrexone anti-SSRI poop-out tip in the pbabble tips section? It look kind of hoky.But Naltrexone is an opioid-antagonist.
And as you may now, these NMDA antagonists involved in synaptic plasticity mitigate opioid
tolerance.So I don't if this is some kind of a "work-backwards" ploy but it looks intriguing.
Btw, did you know that the 5ht-2 receptor is gated to NMDA conductance?
Also, amphetamine releases serotonin via a diffusion mechanism at serotonin receptors.
This whole poop-out thing is tied together in
my shoot from the hip view.Maybe need more poop-out stabilizers?
Something atypical:
Naltrexone, Memantine,
This other medicine Acamprosate (a GabaB med + NMDA antagonist) is fast track FDA approval for
alcoholism for Forest Labs and is being looked at also for treatment resistant bipolar disorder (it is available in europe).I also saw some good darts at calium channel
blockers like nimodipine.Still curious about this Naltrexone dude.
Maybe you can reach that guy by email and find out what his thinking is?Best wishes,
John
poster:johnX2
thread:97813
URL: http://www.dr-bob.org/babble/20020313/msgs/97813.html