Posted by Elizabeth on March 4, 2002, at 1:19:29
In reply to Re: sidetrack from Addiction » Elizabeth, posted by shelliR on March 2, 2002, at 11:35:28
> Elizabeth, stop, PLEASE. You didn't even suggest the oxycontin. My pdoc did and he was the one who prescribed it for me. Not you. You are not even a little bit responsible. Try to let it go.
I understand who did what. For my part, I had believed (prior to your trial) that a person taking opioids for depression would not develop tolerance. I have no doubt that my success with buprenorphine and said belief played a part in what happened. But I also know that you're an opiophile (a word someone came up with for people who need opioids in order to function normally (not necessarily addicts or even daily users)), and that you've been in the unenviable podition of looking for a pdoc willing to prescribe bupe.
Speaking of that, I had a major surprise lately. I made this appointment waaaaay back in December to see this pdoc, and I saw her, and she's okay with the bupe. Well, she wants to read more about it, but she gave me a script. She seems like a good, decent sort. (This after the dreadful guy at the hospital clinic told me that I wouldn't find anyone in the area who would be willing to do it.)
> I would say 7 hours; it's hard to know exactly.
5-7 hours is the range I've observed.
> I am trying to take the second dose while the first dose is still working, so I don't have to wait a second time for almost an hour for me to feel better.
Yeah, I've always done it that way, but still, without the Effexor I was having some ups and downs throughout the day.
> On this dose, I didn't experience depression (after it kicked in) for the whole day and evening.
That's more than 7 hours!
Well anyway, it sounds like it's working great. Hopefully the Lamictal will kick in and then you can reduce your use to PRN so you don't have to worry about tolerance. And there is still a possbility that you won't find that you have to raise the dose. Also, buprenorphine withdrawal is nothing compared to that awful stuff you went through (in that awful hospital).
Rebound depression sucks. I don't know how to deal with that one. I don't get it now, because of the Effexor.
> There is generic temgesic available over the internet, but I don't know where it's made. If it turns out to be made in a country that has strict generic criteria, than I may try it.
I'd like to know, too. Just In Case.
> "buprenorphine is well absorbed in man by the sublingual route, giving plasma level at 2-3 hours after administration which are comparable to those observed at the same time following a similar dose given by a parenteral route."
>
> In somewhat of a round-about way (not giving the reader exact comparisons), they talk about the "delayed onset of peak plasma concentrations following the sublingual dose of buprenorphine" (200 minutes vs. ? for injection). Maybe I missed something, but I can’t find the time of absorption for the parenateral route. Obviously, it's a lot shorter. How long does it take intranasally, and do you overlap doses also?How long to kick in? About an hour. Don't know when peak plasma concentrations are achieved by this route. Yes, I do overlap doses.
Peak effect with IM injection happens at about 1 hour, I think.
> Well, I think I also had refractory depression before I started the nardil--nothing else has worked my whole adult life.
The refractory state I was in after the Nardil pooped out was qualitatively different from the refractory state I was in before I took the Nardil (i.e., depression). Does that make sense?
> I thought you got your driver's license. Are you still trying to learn to drive?
I'm no longer trying. I'm sure you can guess why (I'm a bit shy about discussing it). I'm going to have to depend on being able to get a ride.
Anywayzzz -- looks like we've both got a plan (or plans). I hope things work out for both of us.
Best wishes,
-elizabeth
poster:Elizabeth
thread:93100
URL: http://www.dr-bob.org/babble/20020301/msgs/96271.html