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Re: amphetamine sensitization article

Posted by Hattree on November 19, 2001, at 8:35:37

In reply to Re: amphetamine sensitization article » Hattree, posted by JohnX2 on November 18, 2001, at 22:54:13

I have been diagnosed as ADD inattentive type (distinctly not hyperactive), along with dysthymia.
Stimulants help for both, but I too struggle with the poop out.

I try to deal with it by switching back and forth between different stimulants and taking holidays (not easy--I have two little kids).
Now that I take lamictal, I can go days without the poop out and don't get as much anxiety (also the dysthymia is much better), but stimulant management is still a constant issue. I just got some L-tyrosine to try. Any experience with that?

And yes, I have had to increase the dose over time, but I'm a small doses person, so that only means I'm up to about 7.5 mg/day of dextrostat, taken all at once. I supplement with a cup of coffee in the late afternoon.

>
> The practical implicaition is to understand the
> underlying mechanism so that we can treat
> addiction, tolerance, and sensitization to the
> medication (in this case amphetamine).
>
> Sorry, it is extremely technical, but it is an
> area I have been researching greatly because I
> have a medication poop-out problem; this cruel
> trick where a stimulant or anti-depressant works
> for a few hours and then stops. I believe that
> understand the addiction pathway and how to
> alleviate it will counterattack my cruel friend
> mr. dysthymia.
>
> And yes ironically
> if you need amphetamines for ADD then
> probably the article is a tough read!
>
> Are you ADD or was that just a simple statement
> that the article is a bit boring and complex?
>
> If you are ADD do you take stimulants? Do they
> always work at the same dose over time?
>
> regards,
> -john
>
>
> > Looks interesting but I'm too attention deficited to read it--what is the practical implication?
> > >
> > > I thought this was an interesting article
> > > discussing the means for development of amphetamine
> > > sensitization/tolerance. Interesting conclusion
> > > regarding serotonin being the culprit.
> > >
> > > http://www.ucsf.edu/cnba/Center/JournalClub/Articles/9780.pdf


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poster:Hattree thread:84550
URL: http://www.dr-bob.org/babble/20011113/msgs/84641.html