Posted by SLS on November 4, 2001, at 10:27:45
In reply to Gepirone and Atypical Depression, posted by pat c. on November 3, 2001, at 15:24:24
> Do you know if Gepirone will be available soon?
>
> I heard it's good for atypical depression.
>
> Other than MAOIs and Klonopin, are there
> any other drugs that have been affective against atypical depression.
>
> Will Buspar work? I think I rememeber trying it, and it didn't work.
>
> Thanks.
>
> Pat
Hi Pat.Where did you find the information declaring gepirone as being effective specifically for atypical depression? I know that Columbia has announced wanting to conduct a study of this, but I don't know that they have concluded it.
The only thing I could find on Google regarding FDA approval of gepirone indicated that it is currently under review. I imagine this means that the results of phase III clinical trials have been submitted.
August 8, 2001
http://www.centrere.com/newsroom/press/2001_08_08.html
Gepirone is an azapirone (buspirone, gepirone, ipsapirone, etc.) that is a partial agonist at serotonin 5-HT1a receptors, and is somewhat selective for autoreceptors. Unlike buspirone, a related drug, it does not bind to dopamine receptors and seems to be less sedating. Although gepirone has shown modest anxiolytic (anti-anxiety) effects, it is being developed as an antidepressant. An important feature of gepirone is that its major metabolite, 1-PP, is a potent norepinephrine NE alpha-2 receptor antagonist. This is a property it shares with Remeron.
As anxiolytics, it seems that both buspirone and gepirone can be very effective, but their therapeutic effects often take 2 - 6 weeks to develop. It probably makes sense to co-administer a faster-acting anxiolytic in the beginning.
- Scott
poster:SLS
thread:80214
URL: http://www.dr-bob.org/babble/20011104/msgs/83163.html