Posted by Cam W. on November 1, 2001, at 17:53:37
In reply to Re: Modafinil+Grapefruit Juice » JGalt, posted by JohnX2 on November 1, 2001, at 12:40:30
JGalt & John - A couple constituents (maybe more) of grapefruit, naringenin and 3,4-dihydrobergamottin (sp?) are potent inhibitors of CYP-3A4 in the liver. The only problem with using grapefruit juice is that you would need to know the exact concentration of each of these components in every glass of grapefruit juice, and then adjust the amount of grapefruit juice needed for each dose. Each tree could possibly have unique concentrations of the flavinoids due to varying polymorphisms of the gene(s) that code for them.
HoustonGirl - It is the Celexa that you would have to avoid taking with grapefruit juice. Taking them together could theoretically increase blood levels of Celexa by a significant amount
poster:Cam W.
thread:82868
URL: http://www.dr-bob.org/babble/20011025/msgs/82907.html