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Adverse Effects of Dieting on Antidepressants

Posted by rtc on October 2, 2001, at 9:44:54

My wife takes disipramine, zoloft and tegretol.

She was pleased to find that she can successfully lose weight on the new Weight Watchers program.

However, it has become evident two times after a loss of around 20 pounds that this weight loss adversely affects her blood levels of disipramine. She has fallen out of the theraputic level both times and required a temporary boost in medication. She is now recovering from the latest bout and is very frustrated that it seems she cannot go on a relatively safe diet and not affect her medications.

So the metabolic process of this drug must involve fat, how it's processed through the liver and other things. Could someone please comment on how she can successfully diet? And how exactly is this drug metabolized, and how dieting would affect blood levels?

She is thinking of dieting, and checking levels about every two weeks.

Thanks for the help.


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