Posted by SLS on April 14, 2001, at 18:39:42
In reply to Re: Inderal-vs-Pindolol, posted by JohnX on April 14, 2001, at 5:10:51
> > Is there a difference between Pindolol and Inderal as
> > far as helping with excess adrenaline [rapid heart beat,hyperhydrosis etc..]?
> > The reason I ask is that I am currently without prescription coverage and have found inderal to be more
> > affordable.
> > Thank You
>
> Inderal is more potent. The medication fully blocks a receptor that reacts to adrenaline and causes the symptoms you describe. Pindolol is a partial antagonist at that receptor site.
>
> -John
Hi folks.Both pindolol (Visken) and propanolol (Inderal) antagonize (block) NE beta receptors. It is this action that is responsible for their therapeutic effects in cardiovasculature conditions. However, the property of pindolol that is thought to be most involved in its proposed antidepressant action is the antagonism of serotonergic 5-HT alpha-1a autoreceptors, a receptor that is not affected by propanolol. The antagonism of these autoreceptors actually increases the sensitivity and firing rate of serotonergic neurons. The two drugs are best not thought of as being interchangeable when used for depressions.
- Scott
poster:SLS
thread:59717
URL: http://www.dr-bob.org/babble/20010411/msgs/59867.html