Posted by JohnL on March 14, 2001, at 4:34:30
In reply to Any potent Alpha-1 adrenergic agonists? , posted by JohnX on March 14, 2001, at 2:24:04
>
> Wondering if there are any clean, directed,
> and potent alpha-1 adrenergic agonists that may
> be useful adjuncts to meds like serzone or zyprexa
> which partially antogonize alpha-1 receptors (making
> us fat and dizzy) ?
> -JohnHi John,
You just described Adrafinil. I can say from my own personal experience that it is awesome when combined with SSRIs and/or antipsychotics. It not only acts as a synergistic turbocharger with other meds, but it also counteracts alpha-1 antagonism. It is a direct alpha-1 adrenergic agonist. There were posts here a few months ago that stated that the inventor of Adrafinil claimed that it was NOT an alpha-1 agonist. Despite that, the manufacturer and the label and everything I can find in literature state that it is. It's primary action is as an alpha-1 agonist, and there is clinical evidence suggesting that it also enhances D2 dopamine function. Both of those mechanisms are highly useful in treating depression.Another option could be Nicergoline, though I've never heard of anyone using it. I ordered some a few months ago but never tried it. It gathers dust in a storage box. I can tell you from personal experience though that Adrafinil fits the description of what you are looking for.
John
poster:JohnL
thread:56463
URL: http://www.dr-bob.org/babble/20010310/msgs/56469.html