Posted by JohnX on March 6, 2001, at 2:49:42
In reply to Prozac Zyprexa Study, posted by Neal on March 6, 2001, at 1:06:13
> A Vanderbilt study has found that Prozac and the antipsychotic Zyprexa work better together on treatment-resistant depression patients than either drug alone. Twenty-eight patients were given either Prozac and a placebo, Zyprexa and a placebo, or the two drugs together. After eight weeks, researchers found a "minimal" improvement with Prozac, a "modest" improvement with Zyprexa, and a "significant" improvement with the combination.
This doesn't seem too unexpected. Ideally it seems
one would like a really clean SSRI that blocks the
5ht-2 receptor. Currently there is no medication that does this. Serzone effectively blocks 5ht-2
receptors, but is a weak SSRI and NRI and also
blocks alpha-1 adrenergic receptors which can cause depressive feelings. I'm wondering to
what extent the low dose d2-receptor antagonism
in zyprexa may help depression?I read a few abstracts on new compounds that will
hopefully be more targeted at blocking 5ht-2
receptors while acting as strong SSRI's or 5ht-1
agonists. Hopefully these meds will be quicker
acting with fewer side effects and better response
rates.Zyprasidone looks like a potentially excellent
anti-depressant or complement to an anti-depressant too.Would be interested in any updates.
-John.
poster:JohnX
thread:55673
URL: http://www.dr-bob.org/babble/20010302/msgs/55681.html