Posted by Sunnely on February 25, 2001, at 22:47:51
In reply to Re: Anyone using Trazedon to help sleep w/SRRI's ?, posted by Dave@MT on February 24, 2001, at 22:28:13
"Serotonin syndrome" is a serious condition that can result in death. It is usually caused by increased serotonin stimulation. The most common pharmacological interaction that results in serotonin syndrome is the concurrent use of a monoamine oxidase inhibitor (MAOI) with either tryptophan, tricyclic antidepressants (TCAs) or selective serotonin reuptake inhibitors (SSRIs).
Symptoms of serotonin syndrome may include mood or behavioral changes (confusion, agitation, mania), fever, increased sweating, restlessness, tremor, muscle rigidity, shivering (teeth chattering) or shaking, racing heartbeat, rapid breathing, overactive reflexes, muscle twitchings, diarrhea.
With regards to problem # 2 (priapism - persistent and painful penile erection from trazodone), good that it does not seem to affect you. However, there have been men prescribed trazodone who were not aware of this potential side effect, and learned about it the "hard" way, literarily. :-)
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> Concern #2 is not a problem... :-)
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> What is "serotonin syndrome"?
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> Thanks for your quick response!
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> Dave
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> > Trazodone at low doses (25-50 mg at bedtime as sleeper) and an SSRI is a fairly common combination.
> >
> > A couple of precautions when combining these 2 drugs: 1) serotonin syndrome, and 2) priapism. Case reports of serotonin syndrome have been reported with this trazodone-SRI combination. Usually reversible once the offending drugs are discontinued. Rarely, can be serious and deadly. Priapism is the painful and persistent penile erection not associated with emotional arousal. Most commonly reported with the use of trazodone. If not treated immediately, it could lead to impotence.
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> > ================================================
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> > > I am about off Luvox, no dose for about 7-8 days.
> > >
> > > Had been taking 25-50 mg Trazedon at bedtime to help sleep.
> > >
> > > Has anyone else used low doses of Trazedon to help sleep with SRRI's?
> > >
> > > Appreciate any info.
> > >
> > > Dave@MT
poster:Sunnely
thread:54758
URL: http://www.dr-bob.org/babble/20010221/msgs/54838.html