Posted by anita on January 5, 2001, at 23:07:12
In reply to Is Pindolol+Busirone+ a neuroleptic safe?, posted by AndrewB on January 5, 2001, at 5:58:19
Andrew,
I believe the combo would be "safe," but I don't know if buspirone's D2 antagonism would be high enough to offset the low-dose neuroleptic D2 actions. Sorry, am rusty on buspirone.
Can you please tell me where you saw that low-dose Zyprexa is a D2 autoreceptor antagonist? I have been looking for this info for ages. Do you know if low-dose risperidone is as well?
Thanks,
anita
> Are there any drug interactions or other things to worry about when combining pindolol and buspirone with Zyprexa or amisulpride. Will buspirone's D2 antagonism blunt the action of these neuroleptics?
>
> Ziprasidone's effectiveness and better side effect profile when compared to Zyprexa is speculated to be due to its action as a strong 5-HT1A agonist. When taken in low doses pindolol is a 5-HT1A presynaptic autoreceptor antagonist, thus complementing the moderate 5-HT1A postsynapitc receptor agonist action of buspirone.
>
> Note: At low doses Zyprexa is a D2 autorector antagonist and 5-HT2 receptor antagonist, amisulpride is a D2/D3 autoreceptor antagonist, and Ziprasidone is a D2 autoreceptor antagonist, 5-HT2 antagonist and 5-HT1A agonist.
>
> Thanks for any help,
>
> AndrewB
poster:anita
thread:50944
URL: http://www.dr-bob.org/babble/20001231/msgs/51014.html