Posted by JohnL on November 7, 2000, at 4:27:33
I need some help from my drug expert buddies out there.
As everyone knows, I've done extremely well with low doses of Amisulpride+Adrafinil. I have one and only one side effect. But it's a bad one. Impotence.
My pdoc retired. My GP moved away. Out in the cold, I had to find a new doc. I found one. I spent no time researching, I just sought the GP nearest to where I live. As it turns out, I got lucky, he's awesome. We discussed everything in detail, but still I need feedback from folks here at this board.
His first suggestion was to try Viagra. I didn't like Viagra, but may have to revisit that option if all else fails.
His second suggestion was to try me on one week of extended release Ritalin instead of Adrafinil, and then one week of Adderall. I couldn't believe it! Has this guy been reading Jensen stuff, or what?
If these trials don't turn out well for whatever reason, then next he would have me restart the Adrafinil, and possibly try an alpha-1 antagonist to counteract it on an as-needed basis. I think he mentioned Prazosin. This maybe in combination with Viagra.
In the end, if all these things fail, then he would have me consider longterm trial of Wellbutrin in addition to my other drugs.
My question to you all is this...Do you think an alpha-1 antagonist like Prazosin could counteract the agonist activity of Adrafinil? I read one clinical study where Prazosin did do that to Provigil. But I also wonder if that is something that could happen right away, or whether it is something that would take time. I mean, Adrafinil takes time to work. From what I've read about Prazosin, it takes time too. I wonder if it would have any effect on an as-needed basis.
I also noticed there is a drug called Nicergoline that is also an alpha-1 antagonist which is supposedly much more competitively powerful in site binding than Prazosin.
Anyway, I was surprised to find a doc who had no problem with my current meds, and who is willing to tweek out the details. A soft lifeless genital organ is my concern. He says this soft relaxed muscle condition is common with any alpha or beta agonist. I would welcome any and all feedback from anyone.
Thank you,
John
poster:JohnL
thread:48342
URL: http://www.dr-bob.org/babble/20001102/msgs/48342.html