Posted by R.Anne on November 4, 2000, at 15:29:14
In reply to Brain Serotonin Receptors in Depression , posted by JohnB on November 4, 2000, at 15:10:26
> From the Archives of General Psychiatry, September 2000 issue:
>
> Brain Serotonin2 Receptors in Major Depression
>
> A Positron Emission Tomography Study
>
> Postmortem and brain imaging studies that measured brain serotinin2 (5-HT2) receptors in major depression reported an increase, decrease, and no change compared with controls. In this study, we assessed brain 5-HT2 receptors in 20 depressed patients (mean SD age, 40.1 9.5 years; range, 22-60 years) and 20 healthy controls similar in age (37.2 12.6 years; range, 19-59 years) using positron emission tomography and setoperone labeled with fluorine 18 ([18F]setoperone).
>
> Methods Patients with DSM-IV major depression and healthy controls underwent scanning with [18F]setoperone. All study subjects were drug free for at least 2 weeks.
>
> The 5-HT2 binding images were created using region-to-cerebellum ratios. The differences in 5-HT2 receptor binding potential between the two groups were determined with statistical parametric mapping software and region of interest analysis.
>
> Results There was a significant negative correlation between 5-HT2 receptor binding potential and age in both patients and controls, and the magnitude of this correlation was similar in both groups.
>
> Both statistical parametric mapping and region of interest analyses showed that, compared with healthy controls, depressed patients had significantly lower 5-HT2 receptor binding potential in frontal, temporal, parietal, and occipital cortical regions.
>
> Statistical parametric mapping analysis showed that the mean decrease in 5-HT2 receptor binding potential for the entire cluster in these regions was 22%, and it ranged from 22% to 27% for local maxima within the clusters of significant voxels.
>
> Conclusion: This study suggests that brain 5-HT2 receptors are decreased in patients with major depression.
>
> Arch Gen Psychiatry. 2000;57:850-858
>
> http://archpsyc.ama-assn.org/issues/v57n9/abs/yoa9376.html*****
Thanks, John, good article!
poster:R.Anne
thread:48194
URL: http://www.dr-bob.org/babble/20001102/msgs/48198.html