Posted by SLS on November 3, 2000, at 12:18:23
In reply to Re: Article: Lithium increases brain volume ?, posted by danf on November 3, 2000, at 9:26:20
> After initial evaluation of this study..
>
> let's see, a 3% change in gray matter volume using an MRI... 3% certainly approaches the resolution capability of an MRI..
>
> So Lithium is neurotrophic ?
>
> How about the cells swell a bit ( a few % ) when on Li ?
Hi DanF.Obviously, I posted the wrong URL. Sorry. I think the post included a copy of the full article.
Why MRI? Did you read the article in the Lancet?
Lithium affects the processes by which the cell (cytoplasm) communicates with the nucleus to direct the transcription of specific genes. Two measurable consequences of this change in transduction is a decrease in the synthesis of neurotoxic substances (peptides?) and an increase in the synthesis of neurotrophic and neuroprotective substances.
* HK Manji is considered to be one of the most brilliant researchers who has ever worked at the NIH in the field of neuropsychobiology. I think he is probably second only to Robert M. Post.
----------------------------------------------Enhancement of hippocampal neurogenesis by lithium.
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Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2's neurotrophic effects?
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Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: a role for neurotrophic and neuroprotective effects in manic depressive illness.
----------------------------------------------Signalling pathways in the brain: cellular transduction of mood stabilisation in the treatment of manic-depressive illness.
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poster:SLS
thread:47998
URL: http://www.dr-bob.org/babble/20001102/msgs/48117.html