Posted by Deborah14 on October 21, 2000, at 22:29:35
In reply to Re: Selegeline Patch - Update?, posted by AndrewB on October 20, 2000, at 17:25:27
> Deborah,
>
> This isn't a topic I'm up on but if you do a search of past posts you will find that Adam posted a lot of info. about the patch. As I remember, he found the patch much more effective than the oral selegiline and a lower dose was required to be effective, no dietary restrictions, and there was less of a problem with jitteriness and insomnia. He said some months back was that the patch was unavailable at that point.
>
> You might want to see if a compounding pharmacist can make up a patch or some other transdermal delivery system for selegiline. Try calling Liberty Drug about this, 1-800-58-LIBERTY.
>
> The sleeplessness is caused by selegiline metabolizing into amphetamine and metamphetamine. This suggests that you may find an effective alternate treatment, without the side effects, with the combination of low dose selegiline (5-10mg/day, so only MAO-B inhibition is taking place) along with amphetamine taken during the day (i.e. adderall) and, if necessary, a reversible MAO-A inhibitor (i.e. moclobemide, reportedly few side effects, see Dr. Bob's tips section).
>
> AndrewBAndrew B
Thanks for responding to my post. This is only the second time I've written on this website. I read all the posts about the patch. However, they stopped in the spring and since there has been no new information about the SELEGELINE PATCH, I was hoping that I could find someone who would respond with updated information about whether the study is ongoing. Your idea about having a patch made was terrific. I appreciate the telephone number.
My pdoc has suggested that we look further into obtaining moclobemide from a doc in Canada. However, the posts have not been encouraging about the effectiveness of moclobemide. I was very discouraged after reading them. Selegeline, seems to be the most effective AD me. I have tried the tricyclics, the seretonin re-uptake drugs, etc. Parnate almost killed me.
Can you describe more fully Adderal. I've never heard of it and know nothing about it. In order to counter the side effects of the Selegeline, I take Inderal and klonopin to sleep. I've finally weaned myself off Xanax. However, they are totally ineffective to counter the side effects of 50 mgs Selegeline taken in the morning.
Has anyone on this site been on Selegeline for as long as I have (8 years)? If so, have you found anything more effective for chronic dysthymia?
poster:Deborah14
thread:46818
URL: http://www.dr-bob.org/babble/20001012/msgs/47045.html